反应详情

A mixture of 5-bromosalicylaldehyde (17.7 g), 3-bromoacetylpyridine hydrobromide (25.3 g) and anhydrous potassium carbonate (60.8 g), in 2-butanone (200 ml) was heated under reflux with stirring for 5 hours. The mixture was filtered and the solid was washed with 2-butanone. The combined filtrate and washings were evaporated and the residue was crystallised from methanol to give 5-bromobenzofuran-2-yl pyrid-3-yl ketone (19.2 g), m.p. 144°-145°.

1. temperatureunder reflux
2. filtrationThe mixture was filtered
3. washthe solid was washed with 2-butanone
4. customThe combined filtrate and washings were evaporated
5. customthe residue was crystallised from methanol