Water → HCID 178482484, compound

Participants

Reaction Steps

A mixture of 5-amino-1-(4-[4-trifluoromethylbenzoyl]-3-chloro-5-methylbenzyl)-1,2,3-triazole-4carboxamide (438 mg, 1.00 mmole), methyl iodide (142 mg, 1.00 mmol), and potassium carbonate (138 mg, 1.00 mmole) in N,N-dimethylformamide (2.0 mL) is stirred 48 hours at ambient temperature, poured into water (15 mL), and filtered. Chromatography provides 1-4-[4-trifluoromethylbenzoyl]-3-chloro-5-methyl-benzyl)-5-methylamino-1,2,3-triazole-4-carboxamide.

Provenance & Evidence