Water → HCID 178482484, compound

HRID 280678Notes

Reaction equation

HRID 280678 reaction equation
[NH2:1][C:2]1[N:6](CC2C=C(C)C(C(=O)C3C=CC(C(F)(F)F)=CC=3)=C(Cl)C=2)[N:5]=[N:4][C:3]=1[C:28]([NH2:30])=[O:29].CI.[C:33](=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH3:33][NH:1][C:2]1[NH:6][N:5]=[N:4][C:3]=1[C:28]([NH2:30])=[O:29]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 13649676HCID 13649676, compound

Product 1

HCID 178482484HCID 178482484, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-amino-1-(4-[4-trifluoromethylbenzoyl]-3-chloro-5-methylbenzyl)-1,2,3-triazole-4carboxamide (438 mg, 1.00 mmole), methyl iodide (142 mg, 1.00 mmol), and potassium carbonate (138 mg, 1.00 mmole) in N,N-dimethylformamide (2.0 mL) is stirred 48 hours at ambient temperature, poured into water (15 mL), and filtered. Chromatography provides 1-4-[4-trifluoromethylbenzoyl]-3-chloro-5-methyl-benzyl)-5-methylamino-1,2,3-triazole-4-carboxamide.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-149e14cc8864492c80d759ff226c56fd
Source dataset
uspto-grants-1986_05
Patent number
US04590201

Reaction notes

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