1-Methylpiperazine → 3-(4-Methylpiperazin-1-yl)-isoquinoline

Participants

Reaction Steps

6.5 g of 3-chloroisoquinoline in 30 ml of N-methylpiperazine are boiled under reflux for 48 hours. The reaction mixture is cooled and partitioned between water and toluene, the toluene phase is washed thoroughly with water and, after drying, the solvent is removed in vacuo. The residue is recrystallized from diisopropyl ether, giving 3.8 g of 3-(4-methylpiperazin-1-yl)-isoquinoline, melting point 93°-94° C.; the dihydrochloride decomposes at 255°-257° C.

Provenance & Evidence