反应详情

6.5 g of 3-chloroisoquinoline in 30 ml of N-methylpiperazine are boiled under reflux for 48 hours. The reaction mixture is cooled and partitioned between water and toluene, the toluene phase is washed thoroughly with water and, after drying, the solvent is removed in vacuo. The residue is recrystallized from diisopropyl ether, giving 3.8 g of 3-(4-methylpiperazin-1-yl)-isoquinoline, melting point 93°-94° C.; the dihydrochloride decomposes at 255°-257° C.

1. temperatureunder reflux for 48 hours
2. temperatureThe reaction mixture is cooled
3. custompartitioned between water and toluene
4. washthe toluene phase is washed thoroughly with water
5. customafter drying
6. customthe solvent is removed in vacuo
7. customThe residue is recrystallized from diisopropyl ether