p-Anisoyl chloride → HCID 13025589, compound

HRID 280690Notes

Reaction equation

HRID 280690 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[N:12]1([C:18]2[N:19]=[CH:20][C:21]3[C:26]([CH:27]=2)=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>N1C=CC=CC=1.O>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:15]2[CH2:16][CH2:17][N:12]([C:18]3[N:19]=[CH:20][C:21]4[C:26]([CH:27]=3)=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:13][CH2:14]2)=[O:8])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 130255693-(Piperazin-1-yl)isoquinoline

Product 1

HCID 13025589HCID 13025589, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

9.38 g of 4-methoxybenzoyl chloride are added dropwise to 10 g of 3-(piperazin-1-yl)-isoquinoline, dissolved in 40 ml of pyridine. After stirring for 1 hour at room temperature, the mixture is diluted with water and extracted with ethyl acetate. The ethyl acetate phase is dried and the solvent is removed by evaporation. 5.8 g, melting point 156°-159° C., can be isolated.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate phase is dried
  3. customthe solvent is removed by evaporation
  4. custom5.8 g, melting point 156°-159° C., can be isolated

Sources & evidence

ORD record
ord-c532801cfad04e9a940b085c82fe7225
Source dataset
uspto-grants-1986_05
Patent number
US04590273

Reaction notes

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