HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → N-(2-dimethylaminoethyl)-9-amino-7-nitroacridine-4-carboxamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 7-Nitro-9-oxo-9,10-dihydroacridine-4-carboxylic acid | HCID 542089 | — |
| Reactant | 9-Chloro-7-nitroacridine-4-carbonyl chloride | HCID 23321198 | — |
| Solvent | Phenol | HCID 996 | — |
| Product | N-(2-dimethylaminoethyl)-9-amino-7-nitroacridine-4-carboxamide dihydrochloride | HCID 23321196 | — |
Reaction Steps
The above 7-nitro-4-carboxyacridanone was converted to 7-nitro-9-chloroacridine-4-carbonyl chloride (II, Z=Cl, R2 =7-NO2, R3 =Cl), and treated with N,N-dimethylethylenediamine followed by dry ammonia in phenol by the methods outlined in Example A above to give N-(2-dimethylaminoethyl)-9-amino-7-nitroacridine-4-carboxamide dihydrochloride (compound 20 of Table I), m.p. 316°-318° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04590277 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-d51b380cd14c48299516efe371fd9726 |
| Source note | uspto-grants-1986_05 |