反应详情

The above 7-nitro-4-carboxyacridanone was converted to 7-nitro-9-chloroacridine-4-carbonyl chloride (II, Z=Cl, R2 =7-NO2, R3 =Cl), and treated with N,N-dimethylethylenediamine followed by dry ammonia in phenol by the methods outlined in Example A above to give N-(2-dimethylaminoethyl)-9-amino-7-nitroacridine-4-carboxamide dihydrochloride (compound 20 of Table I), m.p. 316°-318° C.