HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 280724Generated: October 27, 2026
Hydrochloric Acid → 4-Chloromethyl-2,3,5,6-tetrafluorobenzene methanol
https://huagongshe.com/reaction/280724
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol | HCID 4098835 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloromethyl-2,3,5,6-tetrafluorobenzene methanol | HCID 23182352 | — |
Reaction Steps
2,3,5,6-Tetrafluoro-1,4-benzene dimethanol (1 g; 4.8 m.mol) was added to hydrochloric acid 36°Tw (10 ml; 115 m.mol) at 20° C., followed by toluene (10 ml). The mixture was then stirred and warmed to 90° C. and maintained at this temperature for 7 hours to complete the reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04590308 |
|---|
| Source dataset | uspto-grants-1986_05 |
|---|
| ORD ID | ord-ba42e501c7674c1596d547c9d9c21874 |
|---|
| Source note | uspto-grants-1986_05 |
|---|
