Hydrochloric Acid → 4-Chloromethyl-2,3,5,6-tetrafluorobenzene methanol

HRID 280724Notes

Reaction equation

HRID 280724 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH2:9][OH:10])[C:5]([F:11])=[C:4]([F:12])[C:3]=1[CH2:13]O.[ClH:15]>C1(C)C=CC=CC=1>[Cl:15][CH2:13][C:3]1[C:2]([F:1])=[C:7]([F:8])[C:6]([CH2:9][OH:10])=[C:5]([F:11])[C:4]=1[F:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 40988352,3,5,6-Tetrafluoro-1,4-benzenedimethanol

Product 1

HCID 231823524-Chloromethyl-2,3,5,6-tetrafluorobenzene methanol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

2,3,5,6-Tetrafluoro-1,4-benzene dimethanol (1 g; 4.8 m.mol) was added to hydrochloric acid 36°Tw (10 ml; 115 m.mol) at 20° C., followed by toluene (10 ml). The mixture was then stirred and warmed to 90° C. and maintained at this temperature for 7 hours to complete the reaction.

Workup

  1. temperaturemaintained at this temperature for 7 hours
  2. customthe reaction

Sources & evidence

ORD record
ord-ba42e501c7674c1596d547c9d9c21874
Source dataset
uspto-grants-1986_05
Patent number
US04590308

Reaction notes

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