Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)- → Benzene, 1-chloro-2,3-difluoro-5-(trifluoromethyl)-

HRID 280726Notes

Reaction equation

HRID 280726 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](Cl)[C:9]=1[F:10])[C:5]#[N:6].[Cl:12][C:13]1[CH:14]=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:16]=[C:17](Cl)[C:18]=1[F:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:19])[C:9]=1[F:10])[C:5]#[N:6].[Cl:12][C:13]1[CH:14]=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:16]=[C:17]([F:10])[C:18]=1[F:19]

Participants

4

Reactant 2

HCID 157026Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-HCID 136434693,5-Dichloro-4-fluorobenzonitrile

Product 2

HCID 2736496Benzene, 1-chloro-2,3-difluoro-5-(trifluoromethyl)-HCID 136434703-Chloro-4,5-difluorobenzonitrile

Procedure

reacting the 3,5-dichloro-4-fluorobenzonitrile or 3,5-dichloro-4-fluorobenzotrifluoride compound prepared in step (B) with an alkali metal fluoride to form the corresponding 3-chloro-4,5-difluorobenzonitrile or 3-chloro-4,5-difluorobenzotrifluoride compound.

Sources & evidence

ORD record
ord-f4f7478280ff41ffbbf34ba809171653
Source dataset
uspto-grants-1986_05
Patent number
US04590315

Reaction notes

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