Hydrochloric Acid → Tris(dimethylaminomethyl)phosphine trihydrochloride

HRID 28080Notes

Reaction equation

HRID 28080 reaction equation
[CH3:1][N:2]([CH2:4][P:5]([CH2:10][N:11]([CH3:13])[CH3:12])[CH2:6][N:7]([CH3:9])[CH3:8])[CH3:3].[ClH:14]>C(O)C>[ClH:14].[ClH:14].[ClH:14].[CH3:3][N:2]([CH2:4][P:5]([CH2:10][N:11]([CH3:13])[CH3:12])[CH2:6][N:7]([CH3:9])[CH3:8])[CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12717838N,N',N''-[Phosphanetriyltris(methylene)]tris(N-methylmethanamine)

Product 1

HCID 12717839Tris(dimethylaminomethyl)phosphine trihydrochlorideYield 100.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A rubber-capped serum bottle containing 25 ml of ethanol was purged of air with argon, and then charged by means of a syringe with 2.31 g (11.25 mmol) of tris(dimethylaminomethyl)phosphine and 7.00 ml (42.0 mmol) of 6 N hydrochloric acid. The solution, which fumed but remained clear, was shaken for 30 min and then stripped under vacuum, leaving 3.55 g (100% yield) of tris(dimethylaminomethyl)phosphine trihydrochloride as a white, crystalline solid.

Workup

  1. customwas purged of air with argon

Sources & evidence

ORD record
ord-99e16ac29cc94da39b6933c63753d264
Source dataset
uspto-grants-1980_09
Patent number
US04225512

Reaction notes

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