反应详情

温度

0 °C

(ii)(a) To a solution of 84 ml of diisopropylamine in 250 ml of dry tetrahydrofuran at -78° C. under argon were added 39 ml of a 1.6 molar solution of n-butyl lithium in hexane. The mixture was stirred for 10 minutes and then a solution of 12.32 g of methyl 4,4-ethylenedioxy-1,2,3,4-tetrahydro-5,8-dimethoxynaphthalene-2-carboxylate in 75 ml of dry tetrahydrofuran was added rapidly. The mixture was held at -78° C. while stirring for 50 minutes and then 27.8 g of finely ground diperoxo-oxohexamethylphosphoramidomolybdenum (VI) pyridine were added. After a further 80 minutes, the mixture was warmed to 0° C. and stirred for 20 minutes before the addition of 400 ml of water. After 10 minutes, most of the tetrahydrofuran was evaporated in vacuo and the aqueous residue was extracted with five 200 ml portions of ethyl acetate. The combined ethyl acetate extracts were dried over magnesium sulphate, filtered and evaporated to give an oil which was purified by chromatography on silica gel using ethyl acetate/hexane (1:1, vol/vol) for the elution. After the elution of 1.57 g of starting material, there were obtained 7.51 g (58%) of methyl rac-4,4-ethylenedioxy-1,2,3,4-tetrahydro-2-hydroxy-5,8-dimethoxynaphthalene-2-carboxylate in the form of colourless crystals of melting point 74°-75° C.

1. customwas held at -78° C.
2. stirringwhile stirring for 50 minutes
3. waitAfter a further 80 minutes
4. waitAfter 10 minutes
5. custommost of the tetrahydrofuran was evaporated in vacuo
6. extractionthe aqueous residue was extracted with five 200 ml portions of ethyl acetate
7. dry with materialThe combined ethyl acetate extracts were dried over magnesium sulphate
8. filtrationfiltered
9. customevaporated
10. customto give an oil which
11. customwas purified by chromatography on silica gel
12. washfor the elution
13. washAfter the elution of 1.57 g of starting material