Hydrochloric Acid → HCID 53660778, compound

Participants

Reaction Steps

In a mixture of 1 ml of ethanol and 4 ml of sodium hydroxide solution (1N) is dissolved 0.15 g of 3(S)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride obtained in Example 17, and the resulting mixture is allowed to stand for 2 hours and acidified slightly with 1N hydrochloric acid. The deposited powder is collected by filtration, dried and dissolved in 10 ml of ethanol. The insoluble substance is filtered off and filtrate is dried under reduced pressure to give 0.03 g of 3(S)-[1(R)-carboxy-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid as a colorless powder.

Provenance & Evidence