Hydrochloric Acid → HCID 53660778, compound

HRID 280926Notes

Reaction equation

HRID 280926 reaction equation
Cl.C([O:4][C:5]([C@H:7]([NH:16][C@@H:17]1[C:23](=[O:24])[N:22]([CH2:25][C:26]([OH:28])=[O:27])[C:21]2[CH:29]=[CH:30][CH:31]=[CH:32][C:20]=2[O:19][CH2:18]1)[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6])C.Cl>C(O)C.[OH-].[Na+]>[C:5]([C@H:7]([NH:16][C@@H:17]1[C:23](=[O:24])[N:22]([CH2:25][C:26]([OH:28])=[O:27])[C:21]2[CH:29]=[CH:30][CH:31]=[CH:32][C:20]=2[O:19][CH2:18]1)[CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)([OH:6])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70046819HCID 70046819, compound

Product 1

HCID 53660778HCID 53660778, compoundYield 23.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

In a mixture of 1 ml of ethanol and 4 ml of sodium hydroxide solution (1N) is dissolved 0.15 g of 3(S)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride obtained in Example 17, and the resulting mixture is allowed to stand for 2 hours and acidified slightly with 1N hydrochloric acid. The deposited powder is collected by filtration, dried and dissolved in 10 ml of ethanol. The insoluble substance is filtered off and filtrate is dried under reduced pressure to give 0.03 g of 3(S)-[1(R)-carboxy-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid as a colorless powder.

Workup

  1. filtrationThe deposited powder is collected by filtration
  2. customdried
  3. dissolutiondissolved in 10 ml of ethanol
  4. filtrationThe insoluble substance is filtered off
  5. customfiltrate is dried under reduced pressure

Sources & evidence

ORD record
ord-57667b4116244dce95b8ae2353e4b2f6
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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