Lithium Chloride → Benzonitrile, 2,3,6-trichloro-

HRID 28093Notes

Reaction equation

HRID 28093 reaction equation
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]([N+]([O-])=O)[C:3]=1[C:4]#[N:5].[Cl-:14].[Li+].[Cl-].[Al+3].[Cl-].[Cl-]>CN1CCCC1=O>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]([Cl:14])[C:3]=1[C:4]#[N:5]

Participants

5

Reactant 3

HCID 433294Lithium ChlorideHCID 27360202,3-Dichloro-6-nitrobenzonitrileHCID 6451240Aluminum(III) Chloride

Product 1

HCID 3014307Benzonitrile, 2,3,6-trichloro-Yield 91.9%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

10.9 parts of 2,3-dichloro-6-nitrobenzonitrile, 0.84 parts of lithium chloride, 2.22 parts of anhydrous aluminum chloride and 15 parts of N-methyl-2-pyrrolidone were reacted at 180° C. for one hour, and the reaction solution was treated similarly to EXAMPLE B12 to obtain 9.4 parts of 2,3,6-trichlorobenzonitrile with purity of almost 100%. Yield: 91.9%.

Workup

  1. additionthe reaction solution was treated similarly to EXAMPLE B12

Sources & evidence

ORD record
ord-559ca7f36b6e4ec28ab2984c9dcfbf89
Source dataset
uspto-grants-1980_09
Patent number
US04225534

Reaction notes

Loading…