Formaldehyde → 3-hydroxymethyl-5-(4-pyridinyl)-2(1H)-pyridinone

HRID 28108Notes

Reaction equation

HRID 28108 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=2)=[CH:3][CH:2]=1.[CH2:14]=[O:15]>>[OH:15][CH2:14][C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 13289548[3,4'-Bipyridin]-6(1H)-one

Product 1

HCID 205170443-hydroxymethyl-5-(4-pyridinyl)-2(1H)-pyridinone

Procedure

The process which comprises reacting 5-(4-pyridinyl)-2(1H)-pyridinone with excess formaldehyde at an acidic pH to produce 3-hydroxymethyl-5-(4-pyridinyl)-2(1H)-pyridinone.

Sources & evidence

ORD record
ord-4be1b036d75c41e885340180cf860be5
Source dataset
uspto-grants-1980_09
Patent number
US04225601

Reaction notes

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