1,1-Dichloroethane → Butanoic acid, 4-oxo-4-((4-phenyl-2-thiazolyl)amino)-

HRID 28118Notes

Reaction equation

HRID 28118 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC(Cl)C.[C:17]1(=[O:23])[O:22][C:20](=[O:21])[CH2:19][CH2:18]1>>[C:1]1([C:7]2[N:8]=[C:9]([NH:12][C:17](=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 63651,1-DichloroethaneHCID 7922Succinic anhydrideHCID 403022-Amino-4-phenylthiazole

Product 1

HCID 804919Butanoic acid, 4-oxo-4-((4-phenyl-2-thiazolyl)amino)-

Procedure

35.2 g of 4-phenyl 2-amino thiazole are dissolved in 350 ml of boiling 1-2 dichloroethane. To this solution add 20 g of succinic anhydride. The amide formed crystallizes; keep under reflux for five hours and filter. By recrystallization from alcohol there are recovered 39 g (70%) of the product of the formula ##STR12##

Sources & evidence

ORD record
ord-7d95e55333d64ff48f56f2c5454550cc
Source dataset
uspto-grants-1980_09
Patent number
US04225610

Reaction notes

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