Cyclopropanecarbonyl chloride → 4-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid [1-(1-cyclopropyl-methanoyl)-piperidin-4-yl]-amide

HRID 281192Notes

Reaction equation

HRID 281192 reaction equation
[CH:32]1([C:35](=[O:36])[Cl:37])[CH2:33][CH2:34]1.[NH:1]1[CH2:2][CH2:3][CH:4]([NH:7][C:8](=[O:9])[c:10]2[cH:11][nH:12][c:13]3[c:14]2[n:15][cH:16][n:17][c:18]3-[c:19]2[c:20]([O:27][CH2:28][CH:29]3[CH2:30][CH2:31]3)[cH:21][c:22]([O:25][CH3:26])[cH:23][cH:24]2)[CH2:5][CH2:6]1>>[N:1]1([C:35]([CH:32]2[CH2:33][CH2:34]2)=[O:36])[CH2:2][CH2:3][CH:4]([NH:7][C:8](=[O:9])[c:10]2[cH:11][nH:12][c:13]3[c:14]2[n:15][cH:16][n:17][c:18]3-[c:19]2[c:20]([O:27][CH2:28][CH:29]3[CH2:30][CH2:31]3)[cH:21][c:22]([O:25][CH3:26])[cH:23][cH:24]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 668676844-(2-cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide

Product 1

HCID 442081254-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid [1-(1-cyclopropyl-methanoyl)-piperidin-4-yl]-amide

Sources & evidence

ORD record
ord-507a44ea0aa44eaba2774bc69e189758
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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