1-(4-Bromophenyl)-2,2-difluoroethan-1-ol → 2-(4-(2,2-Difluoro-1-hydroxyethyl)phenyl)-8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[Br:49][c:50]1[cH:51][cH:52][c:53]([CH:54]([OH:55])[CH:56]([F:57])[F:58])[cH:59][cH:60]1.[CH3:19][C:20]([CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][C:27]2([CH2:28][CH2:29][N:30]([c:33]3[cH:34][cH:35][c:36]([CH:39]([C:40]([F:41])([F:42])[F:43])[OH:44])[cH:37][cH:38]3)[C:31]2=[O:32])[CH2:45][CH2:46]1)([CH3:47])[CH3:48].[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][C:6]([N:7]1[CH2:8][CH2:9][C:10]2([C:11](=[O:12])[NH:13][CH2:14][CH2:15]2)[CH2:16][CH2:17]1)=[O:18]>>[CH3:19][C:20]([CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][C:27]2([CH2:28][CH2:29][N:30]([c:33]3[cH:34][cH:35][c:36]([CH:39]([CH:40]([F:41])[F:42])[OH:44])[cH:37][cH:38]3)[C:31]2=[O:32])[CH2:45][CH2:46]1)([CH3:47])[CH3:48]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-ee4e55acfed741b9a1032cb68bbda653
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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