Sodium Bicarbonate → HCID 23339016, compound

HRID 28156Notes

Reaction equation

HRID 28156 reaction equation
Cl.Cl.[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[N:11]([CH:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH3:28])[CH2:22][CH2:21]1)[C:12](=[O:19])[CH2:13][C:14]1[S:15][CH:16]=[CH:17][CH:18]=1.C(=O)([O-])O.[Na+]>>[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[N:11]([CH:20]1[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][CH3:28])[CH2:24][CH2:25]1)[C:12](=[O:19])[CH2:13][C:14]1[S:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 23339015HCID 23339015, compound

Product 1

HCID 23339016HCID 23339016, compound

Conditions

Temperature
-10 °C

Procedure

From an aqueous solution of 2.8 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide dihydrochloride, the free base is liberated by alkalization with sodium hydrogen carbonate solution. The free base is extracted with 1,1'-oxybisethane. The extract is dried and evaporated. The oily residue is dissolved in 56 parts of hexane and after cooling to -10° C, the solid free base is precipitated. It is filtered off and dried, yielding 1.6 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide; mp. 62.5° C.

Workup

  1. extractionThe free base is extracted with 1,1'-oxybisethane
  2. customThe extract is dried
  3. customevaporated
  4. dissolutionThe oily residue is dissolved in 56 parts of hexane
  5. customthe solid free base is precipitated
  6. filtrationIt is filtered off
  7. customdried

Sources & evidence

ORD record
ord-c2f8670985624f03afaec71e6f799e02
Source dataset
uspto-grants-1980_09
Patent number
US04225606

Reaction notes

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