Toluene → 2-[6-[(4-tert-Butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-2-methylpropanoic acid methyl ester
Reaction equation
[B-:51]([F:52])([F:53])([F:54])[F:55].[Br:18][c:19]1[cH:20][cH:21][c:22]2[c:23]([cH:50]1)[N:24]([S:37](=[O:38])(=[O:39])[c:40]1[cH:41][cH:42][c:43]([C:46]([CH3:47])([CH3:48])[CH3:49])[cH:44][cH:45]1)[CH2:25][c:26]1[c:27]([n:29][c:30]([C:33]([F:34])([F:35])[F:36])[cH:31][cH:32]1)[NH:28]2.[C:1]([CH:2]([CH3:3])[CH3:4])(=[O:5])[O:6][CH3:7].[C:56]([PH+:57]([C:58]([CH3:59])([CH3:60])[CH3:61])[C:62]([CH3:63])([CH3:64])[CH3:65])([CH3:66])([CH3:67])[CH3:68].[CH3:69][c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1.[CH3:9][Si:10]([N-:11][Si:12]([CH3:13])([CH3:14])[CH3:15])([CH3:16])[CH3:17].[Li+:8]>>[C:1]([C:2]([CH3:3])([CH3:4])[c:19]1[cH:20][cH:21][c:22]2[c:23]([cH:50]1)[N:24]([S:37](=[O:38])(=[O:39])[c:40]1[cH:41][cH:42][c:43]([C:46]([CH3:47])([CH3:48])[CH3:49])[cH:44][cH:45]1)[CH2:25][c:26]1[c:27]([n:29][c:30]([C:33]([F:34])([F:35])[F:36])[cH:31][cH:32]1)[NH:28]2)(=[O:5])[O:6][CH3:7]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-4261418fe2a540a89753453180ca7a71
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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