Chloroform → N-[1-(2,4-difluorophenyl)-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]-4-(2-methylpyrazol-3-yl)thiophene-2-carboxamide

HRID 281680Notes

Reaction equation

HRID 281680 reaction equation
[CH3:1][n:2]1[n:3][cH:4][cH:5][c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:13])[OH:14])[s:10][cH:11]1.[CH:52]([N:53]([CH2:54][CH3:55])[CH:56]([CH3:57])[CH3:58])([CH3:59])[CH3:60].[CH:61]([Cl:62])([Cl:63])[Cl:64].[F:38][c:39]1[cH:40][cH:41][cH:42][c:43]([F:44])[c:45]1[CH2:46][CH:47]([C:48]([OH:49])=[O:50])[NH2:51].[NH2:15][CH:16]([CH2:17][N:18]1[C:19](=[O:28])[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[C:26]1=[O:27])[CH2:29][c:30]1[c:31]([F:37])[cH:32][c:33]([F:36])[cH:34][cH:35]1>>[CH3:1][n:2]1[n:3][cH:4][cH:5][c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:14])[NH:15][CH:16]([CH2:17][N:18]2[C:19](=[O:28])[c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]3[C:26]2=[O:27])[CH2:29][c:30]2[c:31]([F:37])[cH:32][c:33]([F:36])[cH:34][cH:35]2)[s:10][cH:11]1

Participants

6

Reactant 5

HCID 6212ChloroformHCID 81531DiisopropylethylamineHCID 27370432,6-DifluorophenylalanineHCID 578264554-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic AcidHCID 1785108192-[2-amino-3-(2,4-difluorophenyl)propyl]isoindole-1,3-dione

Product 1

HCID 178481804N-[1-(2,4-difluorophenyl)-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]-4-(2-methylpyrazol-3-yl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-2a44131017a748dc975197980a7ef924
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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