反应详情

43.2 g (0.2 mol) of p-nitrobenzylbromide, 200 ml of acetone, 0.2 g of potassium iodide, 24 ml of ethyl thioglycolate (namely a slight excess) and 27.6 g (0.2 mol) of potassium carbonate are successively introduced into a 1 liter 3-necked flask. The mixture is heated under reflux for about 4 hours until the bromine derivative completely disappears; the acetone is evaporated, the oil obtained is taken up in ether and in water, the ether phase is washed with a dilute solution of NaOH to remove the excess thiol, and then with a dilute solution of HCl, the solution is dried over Na2SO4 and the solvent is evaporated off. 49 g (yield: 95%) of the stated product, which is in the form of an orange coloured oil, are obtained.

1. temperatureThe mixture is heated
2. customthe acetone is evaporated
3. customthe oil obtained
4. washthe ether phase is washed with a dilute solution of NaOH
5. customto remove the excess thiol
6. dry with materialwith a dilute solution of HCl, the solution is dried over Na2SO4
7. customthe solvent is evaporated off