5-Bromo-2,4-dichloropyrimidine → tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]-2-methyl-propyl]carbamate

HRID 281869Notes

Reaction equation

HRID 281869 reaction equation
[Br:1][c:2]1[c:3]([Cl:9])[n:4][c:5]([Cl:8])[n:6][cH:7]1.[Br:23][c:24]1[c:25]([NH:26][CH:27]([CH:28]([CH3:29])[CH3:30])[CH2:31][NH:32][C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[n:40][c:41]([Cl:42])[n:43][cH:44]1.[NH2:10][C:11]([CH2:12][NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])([CH3:21])[CH3:22]>>[Br:1][c:2]1[c:3]([NH:10][C:11]([CH2:12][NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])([CH3:21])[CH3:22])[n:4][c:5]([Cl:8])[n:6][cH:7]1

Participants

4

Reactant 3

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 17909918tert-butyl N-(2-amino-2-methylpropyl)carbamateHCID 86695593tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]-3-methyl-butyl]carbamate

Product 1

HCID 86695601tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]-2-methyl-propyl]carbamate

Sources & evidence

ORD record
ord-b8bc832ecfb8429d88d7b7bd5340328a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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