Dichloromethane → Methyl 5-Chloro-2-(1-piperazinyl)benzoate

HRID 282132Notes

Reaction equation

HRID 282132 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21](=[O:22])[O:23][CH3:24])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21](=[O:22])[O:23][CH3:24])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 667586124-(4-Chloro-2-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66757938Methyl 5-Chloro-2-(1-piperazinyl)benzoate

Sources & evidence

ORD record
ord-c7ff200a1dbb480b834e927c4d9e671d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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