Potassium Cation → Methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate

HRID 282586Notes

Reaction equation

HRID 282586 reaction equation
[Br:63][CH2:64][c:65]1[c:66]([C:71]([F:72])([F:73])[F:74])[cH:67][cH:68][cH:69][cH:70]1.[C:1]([Si:2]([CH3:3])([CH3:4])[O:5][CH2:6][c:7]1[n:8][cH:9][c:10]2[n:11](-[c:12]3[s:13][c:14]([C:15]([O:16][CH3:17])=[O:18])[c:19]([OH:20])[cH:21]3)[cH:22][n:23][c:24]2[cH:25]1)([CH3:26])([CH3:27])[CH3:28].[C:29]([CH3:30])([CH3:31])([CH3:32])[Si:33]([O:34][CH2:35][c:36]1[cH:37][c:38]2[c:39]([cH:40][n:41]1)[n:42][cH:43][n:44]2-[c:45]1[cH:46][c:47]([OH:54])[c:48]([C:50](=[O:51])[O:52][CH3:53])[s:49]1)([CH3:55])[CH3:56].[CH3:75][N:76]([CH3:77])[CH:78]=[O:79].[K+:57].[K+:58].[O-:59][C:60]([O-:61])=[O:62]>>[C:29]([CH3:30])([CH3:31])([CH3:32])[Si:33]([O:34][CH2:35][c:36]1[cH:37][c:38]2[c:39]([cH:40][n:41]1)[n:42][cH:43][n:44]2-[c:45]1[cH:46][c:47]([O:54][CH2:64][c:65]2[c:66]([C:71]([F:72])([F:73])[F:74])[cH:67][cH:68][cH:69][cH:70]2)[c:48]([C:50](=[O:51])[O:52][CH3:53])[s:49]1)([CH3:55])[CH3:56]

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 68766004methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-hydroxythiophene-2-carboxylateHCID 68766707methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate

Product 1

HCID 68766097Methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate

Sources & evidence

ORD record
ord-f21324f6da7a4f9ebe5030a52c9a4620
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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