Methanol → [4-(5-Amino-6-methyl-pyridin-2-yl)-piperazin-1-yl]-(2,6-difluoro-phenyl)-methanone

HRID 282602Notes

Reaction equation

HRID 282602 reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:27][OH:28].[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][c:19]([CH3:26])[c:20]([N+:23]([O-:24])=[O:25])[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1>>[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][c:19]([CH3:26])[c:20]([NH2:23])[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 68537965(2,6-Difluoro-phenyl)-[4-(6-methyl-5-nitro-pyridin-2-yl)-piperazin-1-yl]-methanone

Product 1

HCID 59134448[4-(5-Amino-6-methyl-pyridin-2-yl)-piperazin-1-yl]-(2,6-difluoro-phenyl)-methanone

Sources & evidence

ORD record
ord-85ba8e2ecbb347edbc4679a9b1de6915
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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