Imidazole → HCID 23339880, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-cyano-2-(4-chlorophenyl)propyl methane sulfonate (63 g., 0.23 mole), imidazole (62.6 g., 0.9 mole) and N,N-dimethylformamide (3 ml.) is heated with stirring at 130° C. for 24 hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water and dried over magnesium sulfate. Into the ethereal solution is bubbled dry hydrogen chloride gas. The white solid which precipitate is collected and dried to give 38 g. (58.6%) of the expected product, which is identified by nmr.

Provenance & Evidence