反应详情

温度

130 °C

A mixture of 2-cyano-2-(4-chlorophenyl)propyl methane sulfonate (63 g., 0.23 mole), imidazole (62.6 g., 0.9 mole) and N,N-dimethylformamide (3 ml.) is heated with stirring at 130° C. for 24 hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water and dried over magnesium sulfate. Into the ethereal solution is bubbled dry hydrogen chloride gas. The white solid which precipitate is collected and dried to give 38 g. (58.6%) of the expected product, which is identified by nmr.

1. temperatureis heated
2. extractionextracted with ether
3. washThe combined ether extracts are washed with water
4. dry with materialdried over magnesium sulfate
5. customInto the ethereal solution is bubbled dry hydrogen chloride gas
6. customThe white solid which precipitate is collected
7. customdried
8. customto give 38 g