Potassium Cation → 1-{2-Fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]phenyl}pyrrolidin-2-one

HRID 282949Notes

Reaction equation

HRID 282949 reaction equation
[Br:1][c:2]1[c:3]([F:30])[cH:4][c:5](-[c:8]2[cH:9][n:10][c:11]3[n:12]([cH:13]2)[c:14]([C:17]2([c:20]4[cH:21][c:22]5[cH:23][cH:24][cH:25][n:26][c:27]5[cH:28][cH:29]4)[CH2:18][CH2:19]2)[cH:15][n:16]3)[cH:6][cH:7]1.[C:47](=[O:48])([O-:49])[O-:50].[CH2:53]1[O:54][CH2:55][CH2:56][O:57][CH2:58]1.[CH3:37][NH:38][CH:39]1[CH2:40][CH2:41][CH2:42][CH2:43][CH:44]1[NH:45][CH3:46].[Cu:59][I:60].[K+:51].[K+:52].[NH:31]1[C:32](=[O:36])[CH2:33][CH2:34][CH2:35]1>>[c:2]1([N:31]2[C:32](=[O:36])[CH2:33][CH2:34][CH2:35]2)[c:3]([F:30])[cH:4][c:5](-[c:8]2[cH:9][n:10][c:11]3[n:12]([cH:13]2)[c:14]([C:17]2([c:20]4[cH:21][c:22]5[cH:23][cH:24][cH:25][n:26][c:27]5[cH:28][cH:29]4)[CH2:18][CH2:19]2)[cH:15][n:16]3)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 120252-PyrrolidoneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 5510741-N,2-N-dimethylcyclohexane-1,2-diamineHCID 672251686-{1-[6-(4-Bromo-3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline

Product 1

HCID 251453771-{2-Fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]phenyl}pyrrolidin-2-one

Sources & evidence

ORD record
ord-b6219b7890404780b047da153af29599
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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