HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 7beta-Acetoxy-3-hydroxy-2-iodo-estra-1,3,5(10)-trien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3,7beta-Diacetoxy-2-iodo-estra-1,3,5(10)-trien-17-one | HCID 69105006 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7beta-Acetoxy-3-hydroxy-2-iodo-estra-1,3,5(10)-trien-17-one | HCID 11669660 | — |
Reaction Steps
700 mg (1.4 mmol) of 3,7β-diacetoxy-2-iodo-estra-1,3,5(10)-trien-17-one was dissolved in 30 ml of methanol, mixed with 1.0 g of sodium bicarbonate, and the reaction mixture was stirred overnight. Then, it was filtered, and the solution was concentrated by evaporation in a rotary evaporator. Flash chromatography (cyclohexane/ethyl acetate) yielded 402 mg (63%) of colorless crytstals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419972B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-022b672239c24da4b4aa20a12dc2b233 |
| Source note | uspto-grants-2008_09 |