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HRID28341

反应详情

EQUATION

反应方程式

HRID 28341 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC(=O)Oc1cc2c(cc1I)[C@H]1CC[C@]3(C)C(=O)CC[C@H]3[C@@H]1[C@@H](OC(C)=O)C2
HCID69105006

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@H]1Cc2cc(O)c(I)cc2[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@H]12
HCID11669660

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

700 mg (1.4 mmol) of 3,7β-diacetoxy-2-iodo-estra-1,3,5(10)-trien-17-one was dissolved in 30 ml of methanol, mixed with 1.0 g of sodium bicarbonate, and the reaction mixture was stirred overnight. Then, it was filtered, and the solution was concentrated by evaporation in a rotary evaporator. Flash chromatography (cyclohexane/ethyl acetate) yielded 402 mg (63%) of colorless crytstals.

WORKUP

后处理

  1. filtrationThen, it was filtered
  2. concentrationthe solution was concentrated by evaporation in a rotary evaporator
  3. customFlash chromatography (cyclohexane/ethyl acetate) yielded 402 mg (63%) of colorless crytstals