反应详情

温度

110 °C

The mixture of 10 g of 2-amino-3-cyano-4-hydroxyquinoline and 15 ml of phosphoryl chloride is heated under stirring at 110° C. The reaction mixture is cooled down, poured onto 100 ml of ice-water and neutralized with 60 ml of 10% sodium hydroxide solution. The resulting yellow precipitate is filtered off, washed with 50 ml of water. After drying 7.5 g of the title compound is obtained, mp.: 210° C.

1. temperatureis heated
2. temperatureThe reaction mixture is cooled down
3. filtrationThe resulting yellow precipitate is filtered off
4. washwashed with 50 ml of water
5. dry with materialAfter drying 7.5 g of the title compound
6. customis obtained