Pyridine → [2-(4-Chlorophenyl)-2,3-dihydro-1,4-benzothiazin-4-yl]-(1-naphthalen-2-ylsulfonylpyrrolidin-2-yl)methanone

HRID 284095Notes

Reaction equation

HRID 284095 reaction equation
[CH3:39][CH2:40][O:41][C:42](=[O:43])[CH3:44].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[S:9][c:10]3[c:11]([cH:14][cH:15][cH:16][cH:17]3)[NH:12][CH2:13]2)[cH:6][cH:7]1.[cH:18]1[c:19]([S:28](=[O:29])(=[O:30])[N:31]2[CH:32]([C:33](=[O:34])[Cl:35])[CH2:36][CH2:37][CH2:38]2)[cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]12.[cH:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[S:9][c:10]3[c:11]([cH:14][cH:15][cH:16][cH:17]3)[N:12]([C:33]([CH:32]3[N:31]([S:28]([c:19]4[cH:18][c:27]5[c:22]([cH:21][cH:20]4)[cH:23][cH:24][cH:25][cH:26]5)(=[O:29])=[O:30])[CH2:38][CH2:37][CH2:36]3)=[O:34])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 8857Ethyl AcetateHCID 130715242-(4-chlorophenyl)-3,4-dihydro2H-1,4-benzothiazineHCID 135767811-Naphthalen-2-ylsulfonylpyrrolidine-2-carbonyl chloride

Product 1

HCID 18984409[2-(4-Chlorophenyl)-2,3-dihydro-1,4-benzothiazin-4-yl]-(1-naphthalen-2-ylsulfonylpyrrolidin-2-yl)methanone

Sources & evidence

ORD record
ord-b205d1141a0c4102bc5c27a2f92b49e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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