1-Ethyl-4-(prop-2-ynyl)piperazine → N-(4-(2-(3-(4-ethylpiperazin-1-yl)prop-1-ynyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

HRID 284141Notes

Reaction equation

HRID 284141 reaction equation
[CH2:35]([CH3:36])[N:37]1[CH2:38][CH2:39][N:40]([CH2:43][C:44]#[CH:45])[CH2:41][CH2:42]1.[F:1][c:2]1[cH:3][c:4]([N:19]([C:20](=[O:21])[C:22]2([C:25](=[O:26])[NH2:27])[CH2:23][CH2:24]2)[c:28]2[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16]([I:18])[s:17]2>>[F:1][c:2]1[cH:3][c:4]([N:19]([C:20](=[O:21])[C:22]2([C:25](=[O:26])[NH2:27])[CH2:23][CH2:24]2)[c:28]2[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16]([C:45]#[C:44][CH2:43][N:40]1[CH2:39][CH2:38][N:37]([CH2:35][CH3:36])[CH2:42][CH2:41]1)[s:17]2

Participants

3

Reactant 2

HCID 211907411-Ethyl-4-(prop-2-ynyl)piperazineHCID 67347909N-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Product 1

HCID 67348716N-(4-(2-(3-(4-ethylpiperazin-1-yl)prop-1-ynyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-6f45a60ac573444d8faf502b6129ed8c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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