Dimethyl Sulfoxide → 2-[4-(2-Oxo-2,3-dihydro-benzimidazol-1-yl)-piperidin-1-ylmethyl]-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-one

HRID 284193Notes

Reaction equation

HRID 284193 reaction equation
[C:43]([O:44][CH2:45][CH3:46])(=[O:47])[CH3:48].[CH3:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54].[CH3:55][S:56]([CH3:57])=[O:58].[O:27]=[c:28]1[nH:29][c:30]2[c:31]([n:32]1[CH:33]1[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]1)[cH:39][cH:40][cH:41][cH:42]2.[c:1]1([CH3:2])[cH:3][cH:4][c:5]([S:6]([O:7][CH2:11][CH:12]2[CH2:13][O:14][c:15]3[c:16]([c:17]4[c:21]([cH:22][cH:23]3)[NH:20][C:19](=[O:24])[CH2:18]4)[O:25]2)(=[O:8])=[O:9])[cH:10][cH:26]1>>[CH2:11]([CH:12]1[CH2:13][O:14][c:15]2[c:16]([c:17]3[c:21]([cH:22][cH:23]2)[NH:20][C:19](=[O:24])[CH2:18]3)[O:25]1)[N:36]1[CH2:35][CH2:34][CH:33]([n:32]2[c:28](=[O:27])[nH:29][c:30]3[c:31]2[cH:39][cH:40][cH:41][cH:42]3)[CH2:38][CH2:37]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 8058HexaneHCID 8857Ethyl AcetateHCID 886381,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-oneHCID 15381105(8-Oxo-2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-2-yl)methyl 4-methylbenzenesulfonate

Product 1

HCID 699545372-[4-(2-Oxo-2,3-dihydro-benzimidazol-1-yl)-piperidin-1-ylmethyl]-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-one

Sources & evidence

ORD record
ord-a145a7c3570f45099efdee90816a864b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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