Dichloromethane → 2-{4-[3-(1-methyl-1H-imidazol-4-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine

HRID 284389Notes

Reaction equation

HRID 284389 reaction equation
[CH3:1][n:2]1[cH:3][n:4][c:5](-[c:7]2[n:8][n:9][c:10]3[c:11]4[cH:12][c:13](-[c:42]5[cH:43][cH:44][cH:45][cH:46][cH:47]5)[c:14](-[c:20]5[cH:21][cH:22][c:23]([C:26]6([NH:34][C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:27][C:28]7([CH2:29]6)[O:30][CH2:31][CH2:32][O:33]7)[cH:24][cH:25]5)[n:15][c:16]4[cH:17][cH:18][n:19]23)[cH:6]1.[Cl:55][CH2:56][Cl:57].[F:48][C:49]([F:50])([F:51])[C:52]([OH:53])=[O:54]>>[CH3:1][n:2]1[cH:3][n:4][c:5](-[c:7]2[n:8][n:9][c:10]3[c:11]4[cH:12][c:13](-[c:42]5[cH:43][cH:44][cH:45][cH:46][cH:47]5)[c:14](-[c:20]5[cH:21][cH:22][c:23]([C:26]6([NH2:34])[CH2:27][C:28]7([CH2:29]6)[O:30][CH2:31][CH2:32][O:33]7)[cH:24][cH:25]5)[n:15][c:16]4[cH:17][cH:18][n:19]23)[cH:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58229894tert-butyl (2-{4-[3-(1-methyl-1H-imidazol-4-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]oct-2-yl)carbamate

Product 1

HCID 248095872-{4-[3-(1-methyl-1H-imidazol-4-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine

Sources & evidence

ORD record
ord-624cafb8eada48be933c07b9cba1eb69
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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