Citric Acid → t-Butyl 2-methoxy-6-(2-oxopyrrolidin-1-yl)pyridine-4-carboxylate

HRID 284604Notes

Reaction equation

HRID 284604 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C:5](=[O:6])[NH:7][c:8]1[n:9][c:10]([O:21][CH3:22])[cH:11][c:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[cH:13]1.[CH2:23]1[CH2:24][CH2:25][C:26]2=[N:31][CH2:30][CH2:29][CH2:28][N:27]2[CH2:32][CH2:33]1.[O:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1.[OH:34][C:35]([CH2:36][C:37]([C:38](=[O:39])[OH:40])([CH2:41][C:42](=[O:43])[OH:44])[OH:45])=[O:46]>>[CH2:2]1[CH2:3][CH2:4][C:5](=[O:6])[N:7]1[c:8]1[n:9][c:10]([O:21][CH3:22])[cH:11][c:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[cH:13]1

Participants

5

Reactant 4

HCID 311Citric AcidHCID 312751,4-DioxaneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 22253030t-Butyl 2-(4-bromobutyramido)-6-methoxypyridine-4-carboxylate

Product 1

HCID 22252983t-Butyl 2-methoxy-6-(2-oxopyrrolidin-1-yl)pyridine-4-carboxylate

Sources & evidence

ORD record
ord-688c70ffe41146c993a39191d2e84cc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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