Hydrochloric Acid → 4-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline

HRID 284757Notes

Reaction equation

HRID 284757 reaction equation
[CH2:35]([Cl:36])[Cl:37].[CH3:1][O:2][CH2:3][C:4](=[O:5])[Cl:6].[ClH:7].[NH2:8][c:9]1[c:10]([O:33][CH3:34])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:32])[cH:22][c:23]([CH3:31])[c:24]([O:26][C:27](=[O:28])[O:29][CH3:30])[cH:25]3)[n:14][cH:15][n:16][c:17]2[cH:18]1.[cH:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1>>[CH3:1][O:2][CH2:3][C:4](=[O:5])[NH:8][c:9]1[c:10]([O:33][CH3:34])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:32])[cH:22][c:23]([CH3:31])[c:24]([O:26][C:27](=[O:28])[O:29][CH3:30])[cH:25]3)[n:14][cH:15][n:16][c:17]2[cH:18]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 6344DichloromethaneHCID 96623Methoxyacetyl chlorideHCID 10666968[5-[(7-Amino-6-methoxyquinazolin-4-yl)amino]-4-fluoro-2-methylphenyl] methyl carbonate

Product 1

HCID 107894254-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline

Sources & evidence

ORD record
ord-78527dcbea904de69b67ce5d68eb4076
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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