Acetic Acid → 6-Chloro-3-[1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine

HRID 285115Notes

Reaction equation

HRID 285115 reaction equation
[CH3:30][C:31](=[O:32])[OH:33].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([C:11]([CH3:12])([OH:13])[c:14]1[c:15]([F:25])[c:16]3[cH:17][n:18][n:19]([CH3:24])[c:20]3[cH:21][c:22]1[F:23])[cH:9][n:10]2.[I:26].[PH2:27](=[O:28])[OH:29]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([CH:11]([CH3:12])[c:14]1[c:15]([F:25])[c:16]3[cH:17][n:18][n:19]([CH3:24])[c:20]3[cH:21][c:22]1[F:23])[cH:9][n:10]2

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 24841Hydrogen iodideHCID 4124402Phosphinic AcidHCID 581475291-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethanol

Product 1

HCID 581475396-Chloro-3-[1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-bd522ad6de0f48a1bf34a08c4738ee12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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