Formic Acid → (2R,3S)-3-(Tert-butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

HRID 285128Notes

Reaction equation

HRID 285128 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([C:10]([CH2:11][Cl:12])=[O:13])[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[CH:21]([OH:22])=[O:23].[Cl:31][CH2:32][Cl:33].[Cl:60][Rh+:61][C:62]1=[C:70]([CH3:71])[C:68]([CH3:69])=[C:66]([CH3:67])[C:63]1([CH3:64])[CH3:65].[c:34]1([CH3:35])[cH:36][cH:37][c:38]([S:39]([NH:40][CH:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[CH:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[NH2:55])(=[O:56])=[O:57])[cH:58][cH:59]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([CH:10]([CH2:11][Cl:12])[OH:13])[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1

Participants

7

Reactant 6

HCID 284Formic AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 3608242N-(2-amino-1,2-diphenylethyl)-4-methylbenzenesulfonamideHCID 9922259tert-butyl N-(1-benzyl-3-chloro-2-oxo-propyl)carbamateHCID 178425026HCID 178425026, compound

Product 1

HCID 4712659(2R,3S)-3-(Tert-butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

Sources & evidence

ORD record
ord-26839cdc968644e0b2b742a7f2e285bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…