Water → Ethyl 2,5'-bi-1,3-thiazole-4'-carboxylate

HRID 285322Notes

Reaction equation

HRID 285322 reaction equation
[Br:1][c:2]1[c:3]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:4][cH:5][s:6]1.[CH2:12]([Sn:13]([CH2:14][CH2:15][CH2:16][CH3:22])([c:17]1[s:18][cH:19][cH:20][n:21]1)[CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH2:28][CH3:29].[CH3:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[OH2:30].[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[c:2]1(-[c:17]2[s:18][cH:19][cH:20][n:21]2)[c:3]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:4][cH:5][s:6]1

Participants

7

Reactant 6

HCID 962WaterHCID 1140TolueneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 12361218Ethyl 5-bromo-1,3-thiazole-4-carboxylate

Product 1

HCID 59291355Ethyl 2,5'-bi-1,3-thiazole-4'-carboxylate

Sources & evidence

ORD record
ord-e2cd9834046143cc88b730c2f14654a6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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