反应详情

温度

0 °C

A pressure bottle was charged with tetrahydrofuran (50 ml) and cooled to 0° C. Ammonia gas was passed through the tetrahydrofuran until saturated. To this solution was added 4,6-dichloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidine (0.15 g, 0.52 mmol) and the mixture was heated at 75-80° C. for 18 hours. Evaporation of volatiles under reduced pressure provided the hydrochloride salt of 6-chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-yl-amine (0.10 g, 71%).

1. temperaturethe mixture was heated at 75-80° C. for 18 hours
2. customEvaporation of volatiles under reduced pressure