Dichloromethane → 4-N,4-N-dimethyl-1-N-[8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]benzene-1,4-dicarboxamide

HRID 285672Notes

Reaction equation

HRID 285672 reaction equation
[CH2:44]([Cl:45])[Cl:46].[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([C:10](=[O:11])[OH:12])[cH:13][cH:14]1.[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[NH2:15][CH:16]1[CH2:17][c:18]2[c:19]([N:26]3[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]3)[cH:20][cH:21][cH:22][c:23]2[CH2:24][CH2:25]1.[S:40]([Cl:41])([Cl:42])=[O:43]>>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([C:10](=[O:12])[NH:15][CH:16]2[CH2:17][c:18]3[c:19]([N:26]4[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]4)[cH:20][cH:21][cH:22][c:23]3[CH2:24][CH2:25]2)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 110954804-(Dimethylcarbamoyl)benzoic acidHCID 186225218-(4-Methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-amine

Product 1

HCID 184757824-N,4-N-dimethyl-1-N-[8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]benzene-1,4-dicarboxamide

Sources & evidence

ORD record
ord-a225b0a62af54fddb3602b19fbafe117
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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