Dichloromethane → Methyl 7-(4-{[(5-cyclobutyl-3-{[(2,6-dimethylphenyl)oxy]methyl}-4-isoxazolyl)methyl]oxy}phenyl)-3-isoquinolinecarboxylate
Reaction equation
[CH:41]1([c:45]2[c:46]([CH2:60][OH:61])[c:47]([CH2:50][O:51][c:52]3[c:53]([CH3:59])[cH:54][cH:55][cH:56][c:57]3[CH3:58])[n:48][o:49]2)[CH2:42][CH2:43][CH2:44]1.[Cl:76][CH2:77][Cl:78].[O:62]=[C:63]([O:64][CH:65]([CH3:66])[CH3:67])[N:68]=[N:69][C:70]([O:71][CH:72]([CH3:73])[CH3:74])=[O:75].[OH:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]3[cH:12][c:13]([C:18](=[O:19])[O:20][CH3:21])[n:14][cH:15][c:16]3[cH:17]2)[cH:6][cH:7]1.[c:22]1([P:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[O:1]([c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]3[cH:12][c:13]([C:18](=[O:19])[O:20][CH3:21])[n:14][cH:15][c:16]3[cH:17]2)[cH:6][cH:7]1)[CH2:60][c:46]1[c:45]([CH:41]2[CH2:42][CH2:43][CH2:44]2)[o:49][n:48][c:47]1[CH2:50][O:51][c:52]1[c:53]([CH3:59])[cH:54][cH:55][cH:56][c:57]1[CH3:58]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-548d8d0e7cc34b318c8ee88794c05cc4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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