Hydrochloric Acid → 2-Amino-propionic acid 4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl ester

HRID 28588Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:28]=[CH:27][C:12]([CH2:13][O:14][C:15](=[O:26])[C@@H:16]([NH:18]C(OC(C)(C)C)=O)[CH3:17])=[CH:11][CH:10]=2)[CH:5]=[C:4]([C:29]2[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:30]=2[O:36][CH2:37][CH3:38])[N:3]=1.Cl>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:13][O:14][C:15](=[O:26])[CH:16]([NH2:18])[CH3:17])=[CH:27][CH:28]=2)[CH:5]=[C:4]([C:29]2[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:30]=2[O:36][CH2:37][CH3:38])[N:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68984492(S)-2-tert-butoxycarbonylamino-propionic acid 4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl ester

Product 1

HCID 426063002-Amino-propionic acid 4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl esterYield 51%

Procedure

Following the method described in Example 64, (S)-2-tert-butoxycarbonylamino-propionic acid 4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl ester and hydrogen chloride provided the title compound (51% yield).

Sources & evidence

ORD record: ord-29cc1ac0bfbb418bb3ac1a2c53eadfe8
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419984B2

Reaction notes

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