4-Chloroaniline → HCID 59788256, compound

HRID 28624Notes

Reaction equation

HRID 28624 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=2[Cl:15])[N:5]=[C:4]([NH2:16])[N:3]=1.[Cl:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1>>[Cl:15][C:9]1[C:10]([Cl:14])=[CH:11][CH:12]=[CH:13][C:8]=1[C:6]1[N:5]=[C:4]([NH2:16])[N:3]=[C:2]([NH:22][C:21]2[CH:23]=[CH:24][C:18]([Cl:17])=[CH:19][CH:20]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 87645982HCID 87645982, compound

Product 1

HCID 59788256HCID 59788256, compoundYield 42%

Procedure

Following the method described in Example 53, 4-chloro-6-(2,3-dichloro-phenyl)-pyrimidin-2-ylamine and 4-chloroaniline provided the title compound (42% yield). 1H NMR (CD3OD) δ 6.19 (s, 1H, Ar), 7.29 (d, 2H, Ar), 7.31 (d, 2H, Ar) 7.4 (d, 1H, Ar) 7.55 (d, 2H, Ar).

Sources & evidence

ORD record
ord-21cd60faad944deda9ddb59d9eb5b321
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Reaction notes

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