反应详情

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and propan-2-ol provided 4-(5-bromo-2-isopropoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (68% yield).