Dimethylformamide → 4-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-2-cyclooctyl-1,1'-biphenyl

HRID 286682Notes

Reaction equation

HRID 286682 reaction equation
[CH:1]1([c:9]2[c:10](-[c:17]3[c:18]([F:25])[cH:19][cH:20][c:21]([O:23][CH3:24])[cH:22]3)[cH:11][cH:12][c:13]([CH2:15][OH:16])[cH:14]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1.[Cl:30][CH2:31][Cl:32].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[S:26]([Cl:27])([Cl:28])=[O:29]>>[CH:1]1([c:9]2[c:10](-[c:17]3[c:18]([F:25])[cH:19][cH:20][c:21]([O:23][CH3:24])[cH:22]3)[cH:11][cH:12][c:13]([CH2:15][Cl:28])[cH:14]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 57706668(2-Cyclooctyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

Product 1

HCID 577060514-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-2-cyclooctyl-1,1'-biphenyl

Sources & evidence

ORD record
ord-74c365cfc0194c8eaebec2a4714f05be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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